The antibodies used in the Tissue Atlas, are manufactured and made available to fellow researchers by Atlas Antibodies as Triple A Polyclonals. This enormous undertaking, larger even than the Human Genome Project, will transform our understanding of the 37.2 trillion cells in the human body. To ensure good coverage, the Tissue Atlas provides antibody staining in samples from 144 individuals corresponding to 44 different normal tissue types, and samples from 216 cancer patients corresponding to 20 different types of cancer. The Human Cell Atlas is an international collaborative consortium that charts the cell types in the healthy body, across time from development to adulthood, and eventually to old age. Stomach anatomy.
Digestive colonoscopy endocrine microscopic fission dividing paramecium. The protein expression data, currently covering >15,000 (or about 78%) of the protein-coding genes, is derived from antibody-based protein profiling using IHC on tissue microarrays (TMAs). Structure human stomach training medical anatomical stock illustration. The Tissue Atlas contains a comprehensive summary of both mRNA and protein level expression. The Tissue Atlas is based on quantitative transcriptomics on a tissue and organ level combined with protein profiling using tissue microarray-based immunohistochemistry to achieve spatial localization of proteins down to the single-cell level. How to use the Tissue Atlas Quantitative transcriptomics and IHC Not sure where to start? Follow our guide to discover all the information in the Tissue Atlas for your protein of choice. All protein expression profiling data is publicly accessible in the Human Protein Atlas database. In the Tissue Atlas, you can find information regarding the expression profiles of human genes both at the mRNA and protein level and explore the human proteomes in tissues and organs and analyze tissue profiles for specific protein classes. The first version of the Tissue Atlas was launched in 2014, after eleven years of research in the Human Protein Atlas project. These can be viewed in high resolution by clicking on the images.
The Primary data view displays the raw data from the IHC stainings in 44 normal tissues. Image from the Tissue Atlas for the HNF1A gene, showing RNA expression displayed together with a knowledge-based annotation, based on the IHC stainings for the HNF1A protein, in normal tissues. The human protein-coding genes are classified according to their expression in all major organs and tissue types in the human body. The Tissue Atlas section of the Human Protein Atlas is an open-access map of the complete human proteome based on RNA sequencing data and antibody-based profiling. The Tissue Atlas is a fantastic resource if you are interested in basic research into human biology or working in translational medicine, enabling you to ask new questions regarding protein expression in different tissues. Resolving the molecular details of proteome variation in the different tissues and organs of the human body is a necessary step to increase our knowledge of human biology and disease. The Human Protein Atlas is an open source interactive map showing all the known proteins in the human body and how they are distributed in tissues and.